Locomotor muscle group III/IV afferents constrain stroke volume and contribute to exercise intolerance in human heart failure.

ABSTRACT:

Key points

Heart failure patients with reduced ejection fraction (HFrEF) exhibit severe limitations in exercise capacity ( V̇O2 peak). One of the primary peripheral mechanisms suggested to underlie exercise intolerance in HFrEF is excessive locomotor muscle group III/IV afferent feedback; however, this has never been investigated in human heart failure. HFrEF patients and controls performed an incremental exercise test to volitional exhaustion to determine V̇O2 peak with lumbar intrathecal fentanyl or placebo. During exercise, cardiac output, leg blood flow and radial artery and femoral venous blood gases were measured. With fentanyl, compared with placebo, patients with HFrEF achieved a higher peak workload, V̇O2 peak, cardiac output, stroke volume and leg blood flow. These findin

SUBMITTER: Smith JR 

PROVIDER: S-EPMC10039366 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature