Re-assigning the histologic identities of COV434 and TOV-112D ovarian cancer cell lines.

ABSTRACT:

Objective

The development of effective cancer treatments depends on the availability of cell lines that faithfully recapitulate the cancer in question. This study definitively re-assigns the histologic identities of two ovarian cancer cell lines, COV434 (originally described as a granulosa cell tumour) and TOV-112D (originally described as grade 3 endometrioid carcinoma), both of which were recently suggested to represent small cell carcinoma of the ovary, hypercalcemic type (SCCOHT), based on their shared gene expression profiles and sensitivity to EZH2 inhibitors.

Methods

For COV434 and TOV-112D, we re-reviewed the original pathology slides and obtained clinical follow-up on the patients, when available, and performed immunohistochemistry for SMARCA4, SMARCA2 and additiona

SUBMITTER: Karnezis AN 

PROVIDER: S-EPMC10039450 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature