Exploring the putative role of PRDM1 and PRDM2 transcripts as mediators of T lymphocyte activation.

ABSTRACT:

Background

T cell activation and programming from their naïve/resting state, characterized by widespread modifications in chromatin accessibility triggering extensive changes in transcriptional programs, is orchestrated by several cytokines and transcription regulators. PRDM1 and PRDM2 encode for proteins with PR/SET and zinc finger domains that control several biological processes, including cell differentiation, through epigenetic regulation of gene expression. Different transcripts leading to main protein isoforms with (PR +) or without (PR-) the PR/SET domain have been described. Although many studies have established the critical PRDM1 role in hematopoietic cell differentiation, maintenance and/or function, the single transcript contribution has not been investigated before. O

SUBMITTER: Di Zazzo E 

PROVIDER: S-EPMC10039509 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature