A focused review of statistical practices for relating radiation dose-volume exposure and toxicity.

ABSTRACT:

Purpose

Relating dose-volume histogram (DVH) information to patient outcomes is critical for outcomes research in radiation oncology, but this is statistically challenging. We performed this focused review of DVH toxicity studies to characterize current statistical approaches and determine the need for updated reporting recommendations.

Methods and materials

We performed a focused MEDLINE search to identify studies published in 5 radiation oncology specialty journals that associated dosimetry with toxicity outcomes in humans receiving radiotherapy between 2015 and 2021. Elements abstracted from each manuscript included the study outcome, organs-at-risk (OARs) considered, DVH parameters analyzed, summary of the analytic approach, use of multivariable statistics, goodness-of-f

SUBMITTER: McDonald AM 

PROVIDER: S-EPMC10039562 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature