Sex-biased molecular differences in lung adenocarcinoma are ethnic and smoking specific.

ABSTRACT:

Background

Sex-related differences in cancer epidemiology, tumor biology, immune system activity, and pharmacogenomics have been suggested to be important considerations for precision cancer control. Here we elucidated systematically sex biases in genetic variants, gene expression profiles, and immunological landscapes of lung adenocarcinoma patients (LUADs) with different ancestry and smoking status.

Methods

Somatic mutation and mRNA expression data of Asian and Non-Asian LUADs were obtained from public databases. Sex-biased genetic mutations, gene expression, biological pathways, and immune infiltration were identified in the context of smoking status and race.

Results

Among nonsmokers, male-biased mutations were prevalent in Asian LUADs, while few sex-biased mutati

SUBMITTER: Li X 

PROVIDER: S-EPMC10039609 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature