Effects of branched-chain amino acids on Shiraia perylenequinone production in mycelium cultures.

ABSTRACT:

Background

Perylenequinones from Shiraia fruiting bodies are excellent photosensitizers and widely used for anti-cancer photodynamic therapy (PDT). The lower yield of Shiraia perylenequinones becomes a significant bottleneck for their medical application. Branched-chain amino acids (BCAAs) not only serve as important precursors for protein synthesis, but also are involved in signaling pathway in cell growth and development. However, there are few reports concerning their regulation of fungal secondary metabolism. In present study, the eliciting effects of BCAAs including L-isoleucine (L-Ile), L-leucine (L-Leu) and L-valine (L-Val) on Shiraia perylenequinone production were investigated.

Results

Based on the analysis of the transcriptome and amino acid contents of Shiraia in

SUBMITTER: Shen WH 

PROVIDER: S-EPMC10039612 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature