Orientation-dependent indentation reveals the crosslink-mediated deformation mechanisms of collagen fibrils.

ABSTRACT: The spatial arrangement and interactions of the extracellular matrix (ECM) components control the mechanical behavior of tissue at multiple length scales. Changes in microscale deformation mechanisms affect tissue function and are often hallmarks of remodeling and disease. Despite their importance, the deformation mechanisms that modulate the mechanical behavior of collagenous tissue, particularly in indentation and compression modes of deformation, remain poorly understood. Here, we develop an integrated computational and experimental approach to investigate the deformation mechanisms of collagenous tissue at the microscale. While the complex deformation arising from indentation with a spherical probe is often considered a pitfall rather than an opportunity, we leverage this orientation-d

SUBMITTER: Ostadi Moghaddam A 

PROVIDER: S-EPMC10039649 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature