Finding priority bacterial ribosomes for future structural and antimicrobial research based upon global RNA and protein sequence analysis.

ABSTRACT: Ribosome-targeting antibiotics comprise over half of antibiotics used in medicine, but our fundamental knowledge of their binding sites is derived primarily from ribosome structures of non-pathogenic species. These include Thermus thermophilus, Deinococcus radiodurans and the archaean Haloarcula marismortui, as well as the commensal and sometimes pathogenic organism, Escherichia coli. Advancements in electron cryomicroscopy have allowed for the determination of more ribosome structures from pathogenic bacteria, with each study highlighting species-specific differences that had not been observed in the non-pathogenic structures. These observed differences suggest that more novel ribosome structures, particularly from pathogens, are required for a more accurate un

SUBMITTER: Cooper HB 

PROVIDER: S-EPMC10039652 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature