Quality monitoring of Shenmai injection by HPLC pharmacodynamic fingerprinting.

ABSTRACT: A probable problem of disconnection between chemical fingerprints and drug effects for TCMs would be contrary to the original intention of fingerprint research, and limits the development and application of fingerprints. In this study, Shenmai injection, as a treatment dosage form of coronary heart disease, shock, and viral myocarditis clinically, was applied as the research object. The fingerprint of Shenmai injection was constructed, and the pharmacodynamic test of antioxidant effect was carried out to obtain quantitative characteristics and pharmacodynamic data. On this basis, a monitoring model based on the HPLC pharmacodynamic fingerprint was established to evaluate the quality of Shenmai injections from different batches and different manufacturers. Results showed that the optimized

SUBMITTER: Yang G 

PROVIDER: S-EPMC10039686 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature