By what molecular mechanisms do social determinants impact cardiometabolic risk?

ABSTRACT: While it is well known from numerous epidemiologic investigations that social determinants (socioeconomic, environmental, and psychosocial factors exposed to over the life-course) can dramatically impact cardiovascular health, the molecular mechanisms by which social determinants lead to poor cardiometabolic outcomes are not well understood. This review comprehensively summarizes a variety of current topics surrounding the biological effects of adverse social determinants (i.e., the biology of adversity), linking translational and laboratory studies with epidemiologic findings. With a strong focus on the biological effects of chronic stress, we highlight an array of studies on molecular and immunological signaling in the context of social determinants of health (SDoH). The main topics cove

SUBMITTER: Baumer Y 

PROVIDER: S-EPMC10039705 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature