Increase in serum brain-derived neurotrophic factor levels during early withdrawal in severe alcohol users.

ABSTRACT:

Introduction

Changes in brain-derived neurotrophic factor (BDNF) have been linked to the neuroadaptative consequences of chronic alcohol use and associated with disease severity and prognosis. Few studies have evaluated the influence of drug withdrawal and clinical and sociodemographic data on BDNF levels in severe alcohol users.

Objectives

Our goals were (1) to evaluate variation in BDNF levels during alcohol withdrawal and, (2) to assess the influence of putative confounding factors on BDNF levels.

Methods

Our sample consists of 62 men with alcohol use disorder undergoing a detoxification process. Serum BDNF levels were measured using a commercial sandwich-ELISA kit, at two points: before and after the detoxification period.

Results

We found an increase in BD

SUBMITTER: Valerio AG 

PROVIDER: S-EPMC10039723 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature