Collagen-based injectable and self-healing hydrogel with multifunction for regenerative repairment of infected wounds.

ABSTRACT: At present, the development trend of dressing materials is being multifunctional for convenient and long-term nursing care process of some complicated wounds. Here, basing on the theory of wound moist healing, an injectable and self-healing hydrogel comprising of collagen (COL), chitosan (CS) and oxidation modified Konjac glucomannan (OKGM), which acts as a macromolecular cross-linker to construct dynamic Schiff-base bonds was smartly designed. The strategy of introducing the silver nanoparticles (Ag NPs) into the COL-CS-OKGM hydrogel matrix achieved a markedly enhanced antibacterial activity derived from the synergistical effect between the Ag⁺ and the mild photothermal efficacy of Ag NPs, which also improved the local capillary blood circulation of the wound area to further fa

SUBMITTER: Gu H 

PROVIDER: S-EPMC10039733 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature