Strong recommendations from low certainty evidence: a cross-sectional analysis of a suite of national guidelines.

ABSTRACT: Clinical guidelines should be based on a thorough evaluation of the evidence and generally include a rating of the quality of evidence and assign a strength to recommendations. Grading of Recommendations Assessment, Development and Evaluation (GRADE) guidance warns against making strong recommendations when the certainty of the evidence is low or very low, but has identified five paradigmatic situations (e.g. life-threatening situations) where this may be justified. We aimed to characterize the strength of recommendations and certainty of the evidence in Irish National Clinical Guidelines using the GRADE approach. All National Clinical Guidelines from the National Clinical Effectiveness Committee (NCEC) website using the GRADE approach (fully or partially) were included. All recommendation

SUBMITTER: Chong MC 

PROVIDER: S-EPMC10039768 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature