Deficient Radiation Transcription Response in COVID-19 Patients.

ABSTRACT:

Purpose

The ongoing SARS-CoV-2 pandemic has resulted in over 6.3 million deaths and 560 million COVID-19 cases worldwide. Clinical management of hospitalized patients is complex due to the heterogeneous course of COVID-19. Low-dose radiation therapy is known to dampen localized chronic inflammation and has been suggested to be used to reduce lung inflammation in patients with COVID-19. However, it is unknown whether SARS-CoV-2 alters the radiation response and associated radiation exposure related risk.

Methods and materials

We generated gene expression profiles from circulating leukocytes of hospitalized patients with COVID-19 and healthy donors.

Results

The p53 signaling pathway was found to be dysregulated, with mRNA levels of p53, ATM, and CHK2

SUBMITTER: Polozov S 

PROVIDER: S-EPMC10039784 | biostudies-literature | 2023 Jul-Aug

REPOSITORIES: biostudies-literature