Celiac disease and risk of microscopic colitis: A nationwide population-based matched cohort study.

ABSTRACT:

Background

An association has been reported between celiac disease (CD) and microscopic colitis (MC). However, large, population-based cohort studies are rare.

Objective

To systematically examine the association between CD and MC in a large, nationwide cohort.

Methods

We conducted a nationwide population-based matched cohort study in Sweden of 45,138 patients with biopsy-verified CD (diagnosed in 1990-2016), 223,149 reference individuals, and 51,449 siblings of CD patients. Data on CD and MC were obtained from all (n = 28) pathology departments in Sweden. Adjusted hazard ratios (aHRs) were calculated using Cox regression.

Results

During follow-up, 452 CD patients and 197 reference individuals received an MC diagnosis (86.1 vs. 7.5 per 100,000 person-years). Thi

SUBMITTER: Bergman D 

PROVIDER: S-EPMC10039793 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature