The abundances of LTF and SOD2 in amniotic fluid are potential biomarkers of gestational age and preterm birth.

ABSTRACT: Neonates who are born preterm (PT) are usually characterized by immature physiological development, and preterm birth (PTB) is the leading cause of neonatal morbidity and mortality if intensive medical care is not available to PTB neonates. Early prediction of a PTB enables medical personnel to make preparations in advance, protecting the neonate from the subsequent health risks. Therefore, many studies have worked on identifying invasive or noninvasive PT biomarkers. In this study, we collected amniocentesis-derived (at the second trimester of gestation) amniotic fluid (AF) samples. At delivery, AF samples were classified into PTB or full-term birth (FTB). We first applied protein mass spectrometry technology to globally screen AF proteins, followed by specific protein validation with ELI

SUBMITTER: Hsu TY 

PROVIDER: S-EPMC10039869 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature