Phosphate induces inflammation and exacerbates injury from cigarette smoke in the bronchial epithelium.

ABSTRACT: An elevation in serum phosphate-also called hyperphosphatemia-is associated with reduced kidney function in chronic kidney disease (CKD). Reports show CKD patients are more likely to develop lung disease and have poorer kidney function that positively correlates with pulmonary obstruction. However, the underlying mechanisms are not well understood. Here, we report that two murine models of CKD, which both exhibit increased serum levels of phosphate and fibroblast growth factor (FGF) 23, a regulator of phosphate homeostasis, develop concomitant airway inflammation. Our in vitro studies point towards a similar increase of phosphate-induced inflammatory markers in human bronchial epithelial cells. FGF23 stimulation alone does not induce a proinflammatory response in the non-COPD bronchial epi

SUBMITTER: Bollenbecker S 

PROVIDER: S-EPMC10039898 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature