Organic electrochemical transistors as on-site signal amplifiers for electrochemical aptamer-based sensing.

ABSTRACT: Electrochemical aptamer-based sensors are typically deployed as individual, passive, surface-functionalized electrodes, but they exhibit limited sensitivity especially when the area of the electrode is reduced for miniaturization purposes. We demonstrate that organic electrochemical transistors (electrolyte gated transistors with volumetric gating) can serve as on-site amplifiers to improve the sensitivity of electrochemical aptamer-based sensors. By monolithically integrating an Au working/sensing electrode, on-chip Ag/AgCl reference electrode, and Poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate) counter electrode - also serving as the channel of an organic electrochemical transistor- we can simultaneously perform testing of organic electrochemical transistors and traditional elect

SUBMITTER: Ji X 

PROVIDER: S-EPMC10039935 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature