Emotion regulation in bipolar disorder type-I: multivariate analysis of fMRI data.

ABSTRACT:

Background

Bipolar disorder type-I (BD-I) patients are known to show emotion regulation abnormalities. In a previous fMRI study using an explicit emotion regulation paradigm, we compared responses from 19 BD-I patients and 17 matched healthy controls (HC). A standard general linear model-based univariate analysis revealed that BD patients showed increased activations in inferior frontal gyrus when instructed to decrease their emotional response as elicited by neutral images. We implemented multivariate pattern recognition analyses on the same data to examine if we could classify conditions within-group as well as HC versus BD.

Methods

We reanalyzed explicit emotion regulation data using a multivariate pattern recognition approach, as implemented in PRONTO software. The origi

SUBMITTER: Kondo F 

PROVIDER: S-EPMC10039967 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature