Neural ventilatory drive decline as a predominant mechanism of obstructive sleep apnoea events.

ABSTRACT:

Background

In the classic model of obstructive sleep apnoea (OSA), respiratory events occur with sleep-related dilator muscle hypotonia, precipitating increased neural ventilatory 'drive'. By contrast, a drive-dependent model has been proposed, whereby falling drive promotes dilator muscle hypotonia to precipitate respiratory events. Here we determine the extent to which the classic versus drive-dependent models of OSA are best supported by direct physiological measurements.

Methods

In 50 OSA patients (5-91 events/hour), we recorded ventilation ('flow', oronasal mask and pneumotach) and ventilatory drive (calibrated intraoesophageal diaphragm electromyography, EMG) overnight. Flow and drive during events were ensemble averaged; patients were classified as drive dep

SUBMITTER: Gell LK 

PROVIDER: S-EPMC10039972 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature