Pathophysiology, emerging techniques for the assessment and novel treatment of aortic stenosis.

ABSTRACT: Our perspectives on aortic stenosis (AS) are changing. Evolving from the traditional thought of a passive degenerative disease, developing a greater understanding of the condition's mechanistic underpinning has shifted the paradigm to an active disease process. This advancement from the 'wear and tear' model is a result of the growing economic and health burden of AS, particularly within industrialised countries, prompting further research. The pathophysiology of calcific AS (CAS) is complex, yet can be characterised similarly to that of atherosclerosis. Progressive remodelling involves lipid-protein complexes, with lipoprotein(a) being of particular interest for diagnostics and potential future treatment options.There is an unmet clinical need for asymptomatic patient management; no pharm

SUBMITTER: Shah SM 

PROVIDER: S-EPMC10040005 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature