Safety and efficacy of belimumab in older adults with SLE: results of an integrated analysis of clinical trial data.

ABSTRACT:

Objective

Assess the safety and efficacy of belimumab in older adults with SLE.

Methods

This post hoc integrated analysis (GSK Study 116559) included safety data from six randomised, placebo-controlled belimumab trials (BLISS-76, BLISS-52, BLISS-SC, North East Asia study, LBSL02, EMBRACE; n=4170). The BASE study provided additional safety data (n=4003). Efficacy data were from five of the trials. Older adults (≥65 years) were compared with the overall populations of patients with SLE. Patients who had received ≥1 treatment dose were included.

Results

Sixty-three older adults (1.5%) were included in the pooled safety analysis population and 156 (3.9%) in the BASE study. At baseline, older adults had lower disease activity but more organ damage than the overall populati

SUBMITTER: D'Cruz D 

PROVIDER: S-EPMC10040006 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature