Optimal duration of antibiotic treatment for community-acquired pneumonia in adults: a systematic review and duration-effect meta-analysis.

ABSTRACT:

Objectives

To find the optimal treatment duration with antibiotics for community-acquired pneumonia (CAP) in adults.

Design

Systematic review and duration-effect meta-analysis.

Data sources

MEDLINE, Embase and CENTRAL through 25 August 2021.

Eligibility criteria

All randomised controlled trials comparing the same antibiotics used at the same daily dosage but for different durations for CAP in adults. Both outpatients and inpatients were included but not those admitted to intensive care units. We imposed no date, language or publication status restriction.

Data extraction and synthesis

Data extraction by two independent reviewers. We conducted a random-effects, one-stage duration-effect meta-analysis with restricted cubic splines. We tested the non-inferi

SUBMITTER: Furukawa Y 

PROVIDER: S-EPMC10040075 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature