Determination of Clomipramine using eco-friendly solid-contact ionophore-doped potentiometric sensor.

ABSTRACT:

Introduction

Clomipramine is a tricyclic antidepressant acting as a serotonin reuptake inhibitor. Its maximum plasma concentration (C_max) is 13-310 ng/mL, the therapeutic range is 220-500 ng/mL and its toxic effect appears in doses above 900 ng/mL.

Objectives

The fabrication of eco-friendly solid-contact ion-selective electrodes to evaluate the concentration of Clomipramine in different matrices based on disposable screen-printed carbon electrode.

Methods

Disposable screen-printed carbon electrode was utilized as a substrate to fabricate the proposed sensors. The sensors were optimized to determine Clomipramine using calix[4]arene as an ionophore into PVC polymeric membrane to enhance selectivity towards the target analyte. The solid-contact sensor potentia

SUBMITTER: Michael AM 

PROVIDER: S-EPMC10040110 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature