In silico characterization of cysteine-stabilized αβ defensins from neglected unicellular microeukaryotes.

ABSTRACT:

Background

The emergence of multi-resistant pathogens have increased dramatically in recent years, becoming a major public-health concern. Among other promising antimicrobial molecules with potential to assist in this worldwide struggle, cysteine-stabilized αβ (CS-αβ) defensins are attracting attention due their efficacy, stability, and broad spectrum against viruses, bacteria, fungi, and protists, including many known human pathogens.

Results

Here, 23 genomes of ciliated protists were screened and two CS-αβ defensins with a likely antifungal activity were identified and characterized, using bioinformatics, from a culturable freshwater species, Laurentiella sp. (LsAMP-1 and LsAMP-2). Although any potential cellular ligand could be predicted for LsAMP-2; evidences from struct

SUBMITTER: Senra MVX 

PROVIDER: S-EPMC10040121 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature