CeRNA network construction and identification of hub genes as novel therapeutic targets for age-related cataracts using bioinformatics.

ABSTRACT:

Background

The aim of this study is to investigate the genetic and epigenetic mechanisms involved in the pathogenesis of age-related cataract (ARC).

Methods

We obtained the transcriptome datafile of th ree ARC samples and three healthy, age-matched samples and used differential expression analyses to identify the differentially expressed genes (DEGs). The differential lncRNA-associated competing endogenous (ceRNA) network, and the protein-protein network (PPI) were constructed using Cytoscape and STRING. Cluster analyses were performed to identify the underlying molecular mechanisms of the hub genes affecting ARC progression. To verify the immune status of the ARC patients, immune-associated analyses were also conducted.

Results

The PPI network identified the FOXO1 ge

SUBMITTER: Hong Y 

PROVIDER: S-EPMC10040182 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature