SCN1A polymorphisms influence the antiepileptic drugs responsiveness in Jordanian epileptic patients.

ABSTRACT:

Background

The aim of this study was to evaluate whether the voltage-gated sodium channel alpha subunit 1 (SCN1A) gene polymorphisms influence the responsiveness of Jordanian epileptic patients to antiepileptic drugs (AEDs).

Methods

A total of 72 AEDs-treated epileptics were polymerase chain reaction (PCR)-genotyped for six single nucleotide polymorphisms (SNPs), including SCN1A rs2298771, rs3812718, rs3812719, rs2217199, rs2195144 and rs1972445. Genotype and allele distributions in drug-responsive and drug-resistant patients were compared. The six SNPs haplotypes were examined, and the linkage disequilibrium (LD) was assessed.

Results

The genotypes of drug-resistant and drug-responsive groups were in Hardy-Weinberg equilibrium. Three genetic polymorphisms of the SCN1

SUBMITTER: Abduljabbar R 

PROVIDER: S-EPMC10040189 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature