Two-age islet-autoantibody screening for childhood type 1 diabetes: a prospective cohort study.

ABSTRACT:

Background

Early prediction of childhood type 1 diabetes reduces ketoacidosis at diagnosis and provides opportunities for disease prevention. However, only highly efficient approaches are likely to succeed in public health settings. We sought to identify efficient strategies for initial islet autoantibody screening in children younger than 15 years.

Methods

We harmonised data from five prospective cohorts from Finland (DIPP), Germany (BABYDIAB), Sweden (DiPiS), and the USA (DAISY and DEW-IT) into the Type 1 Diabetes Intelligence (T1DI) cohort. 24 662 children at high risk of diabetes enrolled before age 2 years were included and followed up for islet autoantibodies and diabetes until age 15 years, or type 1 diabetes onset, whichever occurred first. Islet autoantibodies measu

SUBMITTER: Ghalwash M 

PROVIDER: S-EPMC10040253 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature