Linking Individual Differences in Personalized Functional Network Topography to Psychopathology in Youth.

ABSTRACT:

Background

The spatial layout of large-scale functional brain networks differs between individuals and is particularly variable in the association cortex, implicated in a broad range of psychiatric disorders. However, it remains unknown whether this variation in functional topography is related to major dimensions of psychopathology in youth.

Methods

The authors studied 790 youths ages 8 to 23 years who had 27 minutes of high-quality functional magnetic resonance imaging data as part of the Philadelphia Neurodevelopmental Cohort. Four correlated dimensions were estimated using a confirmatory correlated traits factor analysis on 112 item-level clinical symptoms, and one overall psychopathology factor with 4 orthogonal dimensions were extracted using a confirmatory factor anal

SUBMITTER: Cui Z 

PROVIDER: S-EPMC10040299 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature