SpheroidAnalyseR-an online platform for analyzing data from 3D spheroids or organoids grown in 96-well plates.

ABSTRACT: Spheroids and organoids are increasingly popular three-dimensional (3D) cell culture models. Spheroid models are more physiologically relevant to a tumor compared to two-dimensional (2D) cultures and organoids are a simplified version of an organ with similar composition. Spheroids are often only formed from a single cell type which does not represent the situation in vivo. However, despite this, both spheroids and organoids can be used in cell migration studies, disease modelling and drug discovery. A drawback of these models is, however, the lack of appropriate analytical tools for high throughput imaging and analysis over a time course. To address this, we have developed an R Shiny app called SpheroidAnalyseR: a simple, fast, effective open-source app that allows the analysis of

SUBMITTER: Barrow R 

PROVIDER: S-EPMC10040300 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature