Third dose of COVID-19 mRNA vaccine closes the gap in immune response between naive nursing home residents and healthy adults.

ABSTRACT:

Background

Nursing home residents, a frail and old population group, respond poorly to primary mRNA COVID-19 vaccination. A third dose has been shown to boost protection against severe disease and death in this immunosenescent population, but limited data is available on the immune responses it induces.

Methods

In this observational cohort study, peak humoral and cellular immune responses were compared 28 days after the second and third doses of the BNT162b2 mRNA COVID-19 vaccine in residents and staff members of two Belgian nursing homes. Only individuals without evidence of previous SARS-CoV-2 infection at third dose administration were included in the study. In addition, an extended cohort of residents and staff members was tested for immune responses to a third vaccine d

SUBMITTER: Pannus P 

PROVIDER: S-EPMC10040352 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature