Association of Sialyl Tn antigen with cervical cancer lymph node status: An NRG oncology/GOG study.

ABSTRACT:

Objective

Detection of lymph node metastases in cervical cancer patients is important for guiding treatment decisions, however accuracies of current detection methods are limited. We evaluated associations of abnormal glycosylation, represented by Tn and STn antigens on mucin (MUC) proteins, in primary tumor specimens with lymph node metastasis or recurrence of cervical cancer patients.

Methods

Surgical specimens were prospectively collected from 139 patients with locally-advanced cervical cancer undergoing lymphadenectomy enrolled in a nation-wide clinical trial (NCT00460356). Of these patients, 133 had primary cervix tumor, 67 had pelvic lymph node (PLN) and 28 had para-aortic lymph node (PALN) specimens. Fixed tissue serial sections were immunohistochemically stained for

SUBMITTER: Benbrook DM 

PROVIDER: S-EPMC10040434 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature