The global landscape of smallpox vaccination history and implications for current and future orthopoxvirus susceptibility: a modelling study.

ABSTRACT:

Background

More than four decades after the eradication of smallpox, the ongoing 2022 monkeypox outbreak and increasing transmission events of other orthopoxviruses necessitate a greater understanding of the global distribution of susceptibility to orthopoxviruses. We aimed to characterise the current global landscape of smallpox vaccination history and orthopoxvirus susceptibility.

Methods

We characterised the global landscape of smallpox vaccination at a subnational scale by integrating data on current demography with historical smallpox vaccination programme features (coverage and cessation dates) from eradication documents and published literature. We analysed this landscape to identify the factors that were most associated with geographical heterogeneity in current vacc

SUBMITTER: Taube JC 

PROVIDER: S-EPMC10040439 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature