Subject-specific factors affecting particle residence time distribution of left atrial appendage in atrial fibrillation: A computational model-based study.

ABSTRACT:

Background

Atrial fibrillation (AF) is a prevalent arrhythmia, that causes thrombus formation, ordinarily in the left atrial appendage (LAA). The conventional metric of stroke risk stratification, CHA₂DS₂-VASc score, does not account for LAA morphology or hemodynamics. We showed in our previous study that residence time distribution (RTD) of blood-borne particles in the LAA and its associated calculated variables (i.e., mean residence time, t_m , and asymptotic concentration, C _∞) have the potential to improve CHA₂DS₂-VASc score. The purpose of this research was to investigate the effects of the following potential confounding factors on LAA t_m and C _∞: (1) pulmonary v

SUBMITTER: Sanatkhani S 

PROVIDER: S-EPMC10040531 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature