Mechanoelectric effects in healthy cardiac function and under Left Bundle Branch Block pathology.

ABSTRACT: Mechanoelectric feedback (MEF) in the heart operates through several mechanisms which serve to regulate cardiac function. Stretch activated channels (SACs) in the myocyte membrane open in response to cell lengthening, while tension generation depends on stretch, shortening velocity, and calcium concentration. How all of these mechanisms interact and their effect on cardiac output is still not fully understood. We sought to gauge the acute importance of the different MEF mechanisms on heart function. An electromechanical computer model of a dog heart was constructed, using a biventricular geometry of 500K tetrahedral elements. To describe cellular behavior, we used a detailed ionic model to which a SAC model and an active tension model, dependent on stretch and shortening velocity and with

SUBMITTER: Petras A 

PROVIDER: S-EPMC10040614 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature