Genome-Wide Association Study on Longitudinal Change in Fasting Plasma Glucose in Korean Population.

ABSTRACT:

Background

Genome-wide association studies (GWAS) on type 2 diabetes mellitus (T2DM) have identified more than 400 distinct genetic loci associated with diabetes and nearly 120 loci for fasting plasma glucose (FPG) and fasting insulin level to date. However, genetic risk factors for the longitudinal deterioration of FPG have not been thoroughly evaluated. We aimed to identify genetic variants associated with longitudinal change of FPG over time.

Methods

We used two prospective cohorts in Korean population, which included a total of 10,528 individuals without T2DM. GWAS of repeated measure of FPG using linear mixed model was performed to investigate the interaction of genetic variants and time, and meta-analysis was conducted. Genome-wide complex trait analysis was used for h

SUBMITTER: Jin H 

PROVIDER: S-EPMC10040618 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature