Metabolic Dysfunction-Associated Fatty Liver Disease and Mortality: A Population-Based Cohort Study.

ABSTRACT:

Background

We investigated whether metabolic dysfunction-associated fatty liver disease (MAFLD) is associated with an elevated risk of all-cause and cardiovascular mortality using a large-scale health examination cohort.

Methods

A total of 394,835 subjects in the Kangbuk Samsung Health Study cohort were enrolled from 2002 to 2012. Participants were categorized by the presence of nonalcoholic fatty liver disease (NAFLD) and MAFLD as follows: normal subjects; patients with both NAFLD and MAFLD; patients with NAFLD only; and patients with MAFLD only. Cox proportional hazards models were used to analyze the risk of mortality.

Results

During a median 5.7 years of follow-up, 20.69% was patients with both NAFLD and MAFLD, 1.51% was patients with NAFLD only, and 4.29% was pat

SUBMITTER: Kim KS 

PROVIDER: S-EPMC10040627 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature