Structural genome variants of Pseudomonas aeruginosa clone C and PA14 strains.

ABSTRACT: Plasticity of Pseudomonas aeruginosa chromosomes is mainly driven by an extended accessory genome that is shaped by insertion and deletion events. Further modification of the genome composition can be induced by chromosomal inversion events which lead to relocation of genes in the affected genomic DNA segments, modify the otherwise highly conserved core genome synteny and could even alter the location of the replication terminus. Although the genome of the first sequenced strain, PAO1, displayed such a large genomic inversion, knowledge on such recombination events in the P. aeruginosa population is limited. Several large inversions had been discovered in the late 1990s in cystic fibrosis isolates of the major clonal lineage C by physical genome mapping, and subsequent work o

SUBMITTER: Klockgether J 

PROVIDER: S-EPMC10040652 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature