Diagnostic performance of integrated whole-body ¹⁸F-FDG PET/MRI for detecting bone marrow involvement in indolent lymphoma: Comparison with ¹⁸F-FDG PET or MRI alone.

ABSTRACT:

Purpose

To investigate the diagnostic performance of integrated whole-body ¹⁸F-FDG PET/MRI for detecting bone marrow involvement (BMI) in indolent lymphoma compared with ¹⁸F-FDG PET or MRI alone.

Methods

Patients with treatment-naive indolent lymphoma who underwent integrated whole-body ¹⁸F-FDG PET/MRI and bone marrow biopsy (BMB) were prospectively enrolled. Agreement between PET, MRI, PET/MRI, BMB, and the reference standard was assessed using kappa statistics. The sensitivity, specificity, accuracy, positive predictive value (PPV), and negative predictive value (NPV) of each method were calculated. A receiver operating characteristic (ROC) curve was used to determine the area under the curve (AUC). AUCs of PET, MRI, PET/MRI, and BMB were c

SUBMITTER: Chen X 

PROVIDER: S-EPMC10040668 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature