Fibrinogen-like protein 1 promotes liver-resident memory T-cell exhaustion in hepatocellular carcinoma.

ABSTRACT:

Background and aims

The key role of tissue-resident memory T (T_RM) cells in the immune regulation of hepatocellular carcinoma (HCC) has been investigated and reported, but the regulatory mechanism of tumor microenvironment on T_RM cells is still unclear. Lymphocyte activating gene 3 (LAG-3) is a promising next-generation immune checkpoint that is continuously expressed due to persistent antigen exposure in the tumor microenvironment. Fibrinogen-like protein 1 (FGL1) is a classical ligand of LAG-3 and can promote T cell exhaustion in tumors. Here, we excavated the effect of FGL1-LAG3 regulatory axis on T_RM cells in HCC.

Methods

The function and phenotype of intrahepatic CD8⁺ T_RM cells in 35 HCC patients were analyzed using

SUBMITTER: Yang C 

PROVIDER: S-EPMC10040674 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature