Tumor immune microenvironment changes are associated with response to neoadjuvant chemotherapy and long-term survival benefits in advanced epithelial ovarian cancer: A pilot study.

ABSTRACT: Little is known about the association between efficacy of neoadjuvant chemotherapy (NACT)/survival and the dynamic change of tumor immune environment (TIME) during treatment in epithelial ovarian cancer (EOC). This study investigated the TIME landscape of treatment-naive EOC tumors using multiplex immunofluorescence and associated the TIME before and after platinum-based NACT with treatment efficacy and prognosis in 33 patients with advanced EOC. NACT significantly increased the density of CD8⁺ T cells (P = 0.033), CD20⁺ B cells (P = 0.023), CD56 NK cells (P = 0.041), PD-1⁺ cells (P = 0.042), and PD-L1⁺CD68⁺ macrophages (P = 0.005) in the tissue specimens. Response to NACT was evaluated using CA125 re

SUBMITTER: Cao G 

PROVIDER: S-EPMC10040680 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature