Alterations in oligodendrocyte transcriptional networks reveal region-specific vulnerabilities to neurological disease.

ABSTRACT: Neurological disease is characterized the by dysfunction of specific neuroanatomical regions. To determine whether region-specific vulnerabilities have a transcriptional basis at cell-type-specific resolution, we analyzed gene expression in mouse oligodendrocytes across various brain regions. Oligodendrocyte transcriptomes cluster in an anatomical arrangement along the rostrocaudal axis. Moreover, regional oligodendrocyte populations preferentially regulate genes implicated in diseases that target their region of origin. Systems-level analyses identify five region-specific co-expression networks representing distinct molecular pathways in oligodendrocytes. The cortical network exhibits alterations in mouse models of intellectual disability and epilepsy, the cerebellar network in ataxia, an

SUBMITTER: Tommasini D 

PROVIDER: S-EPMC10040735 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature