Allergen sensitization stratifies IL-31 production by memory T cells in atopic dermatitis patients.

ABSTRACT:

Background

The role of allergen sensitization in IL-31 production by T cells and specifically in the clinical context of atopic dermatitis (AD) has not been characterized.

Methods

The response to house dust mite (HDM) in purified memory T cells cocultured with epidermal cells from AD patients (n=58) and control subjects (n=11) was evaluated. AD-associated cytokines from culture supernatants, plasma proteins and mRNA expression from cutaneous lesions were assessed and related with the clinical features of the patients.

Results

HDM-induced IL-31 production by memory T cells defined two subsets of AD patients according to the presence or absence of IL-31 response. Patients in the IL-31 producing group showed a more inflammatory profile, and increased HDM-specific (sp) an

SUBMITTER: Sans-de San Nicolas L 

PROVIDER: S-EPMC10040786 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature