A multiscale mechanistic model of human dendritic cells for in-silico investigation of immune responses and novel therapeutics discovery.

ABSTRACT: Dendritic cells (DCs) are professional antigen-presenting cells (APCs) with the unique ability to mediate inflammatory responses of the immune system. Given the critical role of DCs in shaping immunity, they present an attractive avenue as a therapeutic target to program the immune system and reverse immune disease disorders. To ensure appropriate immune response, DCs utilize intricate and complex molecular and cellular interactions that converge into a seamless phenotype. Computational models open novel frontiers in research by integrating large-scale interaction to interrogate the influence of complex biological behavior across scales. The ability to model large biological networks will likely pave the way to understanding any complex system in more approachable ways. We developed a logi

SUBMITTER: Aghamiri SS 

PROVIDER: S-EPMC10040975 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature