Classification of domains in predicted structures of the human proteome.

ABSTRACT: Recent advances in protein structure prediction have generated accurate structures of previously uncharacterized human proteins. Identifying domains in these predicted structures and classifying them into an evolutionary hierarchy can reveal biological insights. Here, we describe the detection and classification of domains from the human proteome. Our classification indicates that only 62% of residues are located in globular domains. We further classify these globular domains and observe that the majority (65%) can be classified among known folds by sequence, with a smaller fraction (33%) requiring structural data to refine the domain boundaries and/or to support their homology. A relatively small number (966 domains) cannot be confidently assigned using our automatic pipelines, thus deman

SUBMITTER: Schaeffer RD 

PROVIDER: S-EPMC10041065 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature