Chronic CD27-CD70 costimulation promotes type 1-specific polarization of effector Tregs.

ABSTRACT:

Introduction

Most T lymphocytes, including regulatory T cells, express the CD27 costimulatory receptor in steady state conditions. There is evidence that CD27 engagement on conventional T lymphocytes favors the development of Th1 and cytotoxic responses in mice and humans, but the impact on the regulatory lineage is unknown.

Methods

In this report, we examined the effect of constitutive CD27 engagement on both regulatory and conventional CD4⁺ T cells in vivo, in the absence of intentional antigenic stimulation.

Results

Our data show that both T cell subsets polarize into type 1 Tconvs or Tregs, characterized by cell activation, cytokine production, response to IFN-γ and CXCR3-dependent migration to inflammatory sites. Transfer experiments suggest tha

SUBMITTER: Bowakim-Anta N 

PROVIDER: S-EPMC10041113 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature