L-type Ca²⁺ channels mediate regulation of glutamate release by subthreshold potential changes.

ABSTRACT: Subthreshold depolarization enhances neurotransmitter release evoked by action potentials and plays a key role in modulating synaptic transmission by combining analog and digital signals. This process is known to be Ca²⁺ dependent. However, the underlying mechanism of how small changes in basal Ca²⁺ caused by subthreshold depolarization can regulate transmitter release triggered by a large increase in local Ca²⁺ is not well understood. This study aimed to investigate the source and signaling mechanisms of Ca²⁺ that couple subthreshold depolarization with the enhancement of glutamate release in hippocampal cultures and CA3 pyramidal neurons. Subthreshold depolarization increased presynaptic Ca²⁺ levels, the frequency of spontaneous rele

SUBMITTER: Lee BJ 

PROVIDER: S-EPMC10041175 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature