Peptidyl arginine deiminase 4 deficiency protects against subretinal fibrosis by inhibiting Muller glial hypercitrullination.

ABSTRACT: Retinal scarring with vision loss continues to be an enigma in individuals with advanced age-related macular degeneration (AMD). Müller glial cells are believed to initiate and perpetuate scarring in retinal degeneration as these glial cells participate in reactive gliosis and undergo hypertrophy. We previously showed in the murine laser-induced model of choroidal neovascularization that models wet-AMD that glial fibrillary acidic protein (GFAP) expression, an early marker of reactive gliosis, increases along with its posttranslational modification citrullination. This was related to increased co-expression of the citrullination enzyme peptidyl arginine deiminase-4 (PAD4), which also colocalizes to GFAP filaments. However, whether such hypercitrullination in Müller glial drives fibrotic pa

SUBMITTER: Palko SI 

PROVIDER: S-EPMC10041335 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature