Facet joint degeneration-An initial procedure of the cervical spine degeneration.

ABSTRACT:

Objective

This study aims to emphasize the initiating role of facet joint (FJ) degeneration in the process of cervical spine degeneration induced by tangential load, and we further validate it in a novel cervical spine degeneration animal model.

Methods

The characteristics of cervical degeneration in patients of different ages were summarized through case collection. In the rat models, Hematoxylin-Eosin, Safranin O staining, and micro-computed tomography were used to show the histopathological changes and bone fiber structure of FJ and the height of intervertebral disc (IVD) space. The ingrowth of nociceptive sensory nerve fibers was observed by immunofluorescence staining.

Results

FJ degeneration without IVDs degeneration was more common in people with cervical spond

SUBMITTER: Shang Q 

PROVIDER: S-EPMC10041371 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature