Efficient Synthesis of 3-Mercaptoindoles via HI-Promoted Sulfenylation of Indoles with Sodium Sulfinates.

ABSTRACT: A new direct sulfenylation method of indoles by sodium sulfinates and hydroiodic acid was developed giving variety of 3-sulfenylindoles in high yields under mild conditions without using any catalysts or other additives. In situ-generated RS-I species are supposed to be mainly responsible for the key electrophilic alkyl- or aryl-thiolation process.

SUBMITTER: Sun S 

PROVIDER: S-EPMC10041381 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature